Patient details
- Name
- Mrs H.M.
- Age / sex
- 48-year-old woman
- Occupation
- Schoolteacher
- Marital status
- Married, two children
- Seen
- Breast clinic, 09:30
- Clerked
- Breast clinic, 09:45
- Source
- Patient herself, reliable
- Referred by
- Family doctor
Presenting complaint
“A lump in my left breast for six weeks.”
History of presenting complaint
Mrs H.M. was well until six weeks ago, when she felt a lump in the upper outer part of her left breast while showering. It was then the size of a chickpea and is now the size of a walnut. It is painless and feels hard, and it does not change in size or tenderness with her periods. She has noticed no discharge from the nipple, no change in the shape or direction of the nipple, and no dimpling, redness or ulceration of the skin. She has not felt a lump in either armpit, and her right breast is normal. She has had no previous breast lumps, biopsies or breast operations, no injury to the breast, and no fever; she is not breastfeeding. She has no bone or back pain, no cough or breathlessness, no jaundice or abdominal swelling, no headache and no weight loss. Her periods began at the age of 11 and are still regular, the last one starting ten days ago. She had her first child at 31 and has two children, each breastfed for about three months. She took the oral contraceptive pill for eight years in the past and has never used hormone replacement. She has had no radiotherapy to the chest. Her mother was treated for breast cancer at 52 and a maternal aunt had ovarian cancer. She has never had a mammogram. She is frightened that this is the same disease her mother had.
Past medical history
No chronic illness.
Past surgical history
One caesarean section in 2012, with no complications.
Drugs and allergies
No regular medication. No known drug allergies.
Family history
Mother: breast cancer at 52, alive. Maternal aunt: ovarian cancer at 60. No male breast cancer in the family.
Social history
Does not smoke or drink alcohol. Lives with her husband and two children.
General examination
A well-looking woman, anxious but comfortable. Not pale, not jaundiced. Weight 68 kg, with no recent change.
Breast examination
Examined with consent, in the presence of a female chaperone, undressed to the waist.
Inspection
Sitting with arms by her sides, then raised above the head, then with hands pressed on the hips. The breasts are of similar size. On raising the arms, dimpling of the skin appears over the upper outer quadrant of the left breast. Both nipples are at the same level and point outwards, with no discharge and no scaling. No redness, no orange-peel skin, no visible veins, no scars.
Palpation
Lying at 45 degrees with the hand behind the head. The right breast was examined first and is normal. In the left breast there is a single lump in the upper outer quadrant, at 2 o'clock, 5 cm from the nipple. It measures 3 by 2.5 cm, is hard, with an irregular surface and an ill-defined edge, and is not tender or warm. The skin over it dimples when the lump is moved, so it is tethered to the skin. It moves freely over the chest wall both with the pectoral muscle relaxed and with it tensed. No other lumps. No discharge when she presses the nipple herself.
Lymph nodes
Left axilla: two firm, mobile, non-tender nodes of about 1 cm in the central group. Right axilla: no nodes. No nodes in either supraclavicular fossa.
Other systems
Chest: clear, no pleural effusion.
Abdomen: liver not palpable, no ascites.
Spine: no tenderness on percussion.
Arms: no swelling.
Summary
Provisional diagnosis
Carcinoma of the left breast, clinical stage T2 N1 M0.
Plan
- Complete the triple assessment: clinical examination, imaging and tissue diagnosis.
- Mammography of both breasts and ultrasound of the left breast and axilla.
- Core needle biopsy of the lump, with hormone receptor and HER2 status. Sampling of an axillary node if abnormal on ultrasound.
- Results to be given by the consultant, and the case discussed at the multidisciplinary meeting.
- Referral for genetic counselling in view of the family history.
Differential diagnosis of a breast lump
Use the age of the patient and the character of the lump. Say which features are for and against in your patient.
| Diagnosis | Points to it in the history | Points to it on examination | In this patient |
|---|---|---|---|
| Malignant | |||
| Carcinoma of the breast | Over 35, painless growing lump, family history, no change with periods | Hard, irregular, ill-defined, tethered to skin, axillary nodes | Most likely |
| Phyllodes tumour | Rapidly growing large lump, age 40 to 50 | Large, smooth, mobile, lobulated; skin stretched and shiny | Lump is small and irregular |
| Benign lumps | |||
| Fibroadenoma | Age 15 to 30, slow growing, painless | Firm, smooth, well-defined, very mobile | Wrong age, wrong character |
| Breast cyst | Age 35 to 50, appears quickly, may be tender | Smooth, tense or fluctuant, well-defined | Hard and irregular |
| Fibrocystic change | Lumpiness and pain in both breasts that vary with the cycle | Ill-defined nodular areas, often both upper outer quadrants | No cyclical change |
| Fat necrosis | Injury or surgery to the breast, sometimes forgotten | Hard, irregular, may tether the skin; imitates cancer | No injury; biopsy decides |
| Breast abscess | Breastfeeding, pain, fever | Hot, red, tender, fluctuant | Not lactating, not tender |
| Duct ectasia and periductal mastitis | Smoker, around menopause, green or creamy discharge | Lump beneath the areola, slit-like nipple retraction | Lump is far from the nipple |
| Intraductal papilloma | Blood-stained discharge from a single duct | Small lump near the areola or none | No discharge |
| Galactocele | Recently stopped breastfeeding | Smooth, mobile, non-tender cyst | Not applicable |
| Lipoma | Slow growing for years | Soft, lobulated | Hard lump |
| Not from the breast | |||
| Sebaceous cyst | Lump in the skin with a punctum | Moves with the skin | Lump is in the breast |
| Costochondritis | Pain over the ribs, worse on movement | Tender rib junction, no breast lump | No pain |
Clinical signs related to this case
The signs you should look for in any patient with a breast lump. For each one, know how to elicit it and what a positive result means.
| Sign | How to elicit it, or what you see | What it means |
|---|---|---|
| Signs in the skin | ||
| Skin dimpling | Appears or deepens when the arms are raised or the lump is moved | Tethering: the tumour is pulling on the ligaments of the breast |
| Orange-peel skin | Thickened skin with pitting at the hair follicles | Skin lymphatics are blocked by tumour: locally advanced cancer |
| Redness and warmth of the whole breast | Swollen, red, warm breast without fever, not breastfeeding | Inflammatory breast cancer, often mistaken for infection |
| Ulceration or skin nodules | Tumour breaking through the skin, or small nodules around it | Locally advanced cancer |
| Signs at the nipple | ||
| Recent nipple retraction | Nipple pulled in or changed direction over weeks or months | Cancer beneath the nipple. A slit-like retraction for years suggests duct ectasia. |
| Blood-stained discharge from one duct | Ask the patient to express it herself; note the colour and whether one duct or several | Intraductal papilloma or cancer |
| Eczema of the nipple (Paget's disease) | Red, scaly, crusted nipple on one side that destroys the nipple | Underlying breast cancer. Ordinary eczema affects the areola, both sides, and spares the nipple. |
| Signs of the lump | ||
| Fixation to the pectoral muscle | Mobility of the lump is lost when she presses her hands on her hips | Tumour has invaded the muscle |
| Fixation to the chest wall | Lump cannot be moved even with the muscle relaxed | Tumour has invaded the chest wall: T4 |
| Very mobile lump | Firm smooth lump that slips away from the fingers | Fibroadenoma, the “breast mouse” |
| Fluctuation | Smooth, tense lump that transmits pressure between two fingers | Cyst |
| Signs of spread | ||
| Axillary nodes | Hard nodes; mobile, or matted together and fixed | Mobile: N1. Fixed or matted: N2. |
| Supraclavicular node | Hard node above the clavicle on the same side | N3 disease |
| Swelling of the arm | Whole arm swollen on the affected side | Axillary lymphatics blocked by tumour, or previous axillary surgery |
| Tender spine, hard liver, pleural effusion | Percuss the spine, palpate the liver, percuss the lung bases | Distant spread |
Teaching case. The patient is fictional and written to illustrate format and reasoning. Local protocols decide investigation and treatment.