Patient details
- Name
- Mrs L.K.
- Age / sex
- 34-year-old woman
- Occupation
- Accountant
- Marital status
- Married, two children
- Seen
- Endocrine surgery clinic, 12:00
- Clerked
- Endocrine surgery clinic, 12:15
- Source
- Patient herself, reliable
- Referred by
- Family doctor
Presenting complaint
“A swelling in the front of my neck for four months.”
History of presenting complaint
Mrs L.K. was well until four months ago, when she noticed a swelling in the lower part of the front of her neck, to the right of the midline, while looking in the mirror. It has grown slowly since. It is not painful and has never suddenly enlarged. Her voice has not changed. She has no difficulty swallowing food or drink, no difficulty breathing, including when lying flat, and no noisy breathing. Her weight is steady and her appetite normal. She does not feel unusually hot or cold, does not sweat more than usual, and has no palpitations, tremor, anxiety or trouble sleeping. Her bowels are regular, and her periods are regular and unchanged. She is not more tired than usual, and her skin and hair have not changed. She has noticed no change in her eyes, no double vision and no grittiness. She has felt no other lumps in the neck. She had no radiotherapy to the head, neck or chest as a child. No one in her family has had thyroid cancer or other gland tumours, though her mother had a goitre removed that was benign. She has no bone pain, cough or weight loss. She has lived all her life in a hill village.
Past medical history
No chronic illness. No previous thyroid disease or thyroid blood tests.
Past surgical history
Two normal deliveries. No operations.
Drugs and allergies
No regular medication. No amiodarone, lithium or thyroid tablets. No known drug allergies.
Family history
Mother: thyroid operation for a benign goitre at 50. No thyroid cancer.
Social history
Does not smoke. Uses iodised salt at home.
General examination
A calm, well-looking woman, sitting comfortably and not sweating. Speech and voice normal. Weight 63 kg.
Hands: warm and dry, no tremor of the outstretched fingers, no red palms, nails normal.
Eyes: no lid retraction, no lid lag, no protrusion of the eyes, movements full.
Legs: no thickening of the skin over the shins. Ankle reflexes normal, with normal relaxation.
Examination of the neck
Seated, neck slightly extended and exposed to the clavicles.
Inspection
A swelling is visible in the lower anterior neck on the right. It moves upwards when she swallows a sip of water and does not move when she puts out her tongue. No scars, no redness, no dilated veins over the neck or upper chest.
Palpation
From behind. A single nodule in the right lobe of the thyroid, 3 by 2.5 cm, firm, smooth, not tender, moving with swallowing. Its lower border can be felt above the clavicle. The left lobe and isthmus are not palpable. Trachea central. No enlarged lymph nodes in the anterior or posterior triangles or the supraclavicular fossae. Both carotid pulses felt.
Percussion and auscultation
Resonant over the upper sternum. No bruit over the gland.
Pemberton's test
Negative: no flushing of the face or distension of neck veins on raising both arms for one minute.
Other systems
Chest: clear.
Heart: first and second heart sounds normal, no murmurs.
Abdomen: soft, no masses.
Summary
Provisional diagnosis
Solitary thyroid nodule of the right lobe, clinically euthyroid. Malignancy to be excluded.
Plan
- Thyroid stimulating hormone, with free T4 if it is abnormal. Serum calcium.
- Ultrasound of the thyroid and neck nodes.
- Ultrasound-guided fine needle aspiration if the ultrasound features and size call for it.
- Isotope scan only if the thyroid stimulating hormone is suppressed.
- Examination of the vocal cords before any operation.
Differential diagnosis of a swelling in the front of the neck
First decide whether it is thyroid. Then, for a thyroid nodule, list benign before malignant. Then give the non-thyroid causes by position.
| Diagnosis | Points to it in the history | Points to it on examination | In this patient |
|---|---|---|---|
| Thyroid: benign | |||
| Dominant nodule of a multinodular goitre | Long-standing, slow growing, family history of goitre | One nodule felt, others found on ultrasound | Common; ultrasound decides |
| Colloid nodule or cyst | Slow growing, or sudden painful enlargement if it bleeds | Smooth, firm or tense | Possible |
| Follicular adenoma | Slowly growing single nodule | Smooth, firm, mobile | Possible; cannot be told from cancer on cytology alone |
| Toxic adenoma | Symptoms of an overactive thyroid | Fast pulse, tremor, single nodule | Clinically euthyroid |
| Thyroiditis | Painful gland after a viral illness, or long-standing with underactivity | Tender, or firm and rubbery gland | Not tender, euthyroid |
| Thyroid: malignant | |||
| Papillary carcinoma | Young adult, childhood neck radiation, neck nodes | Firm nodule, nodes on the same side | No nodes, but must be excluded |
| Follicular carcinoma | Middle age, long-standing nodule, bone pain | Firm nodule | Needs tissue diagnosis |
| Medullary carcinoma | Family history of gland tumours, diarrhoea, flushing | Hard nodule, nodes | No family history |
| Anaplastic carcinoma | Elderly, growth over weeks, hoarseness, noisy breathing | Hard, fixed mass | Wrong age, wrong pace |
| Lymphoma | Rapid growth in a gland with long-standing thyroiditis | Large firm gland | No such history |
| Midline, not thyroid | |||
| Thyroglossal cyst | Child or young adult, midline lump, sometimes infected | Moves up when the tongue is put out | Does not move with the tongue |
| Dermoid cyst | Painless midline lump | Does not move with swallowing or the tongue | Moves with swallowing |
| Side of the neck | |||
| Lymph node | Sore throat, fever, night sweats, weight loss, or a cancer elsewhere | Does not move with swallowing; may be multiple | Moves with swallowing |
| Branchial cyst | Young adult, smooth swelling in the upper neck | At the front edge of the muscle in the upper third | Wrong position |
| Carotid body tumour | Slow growing lump at the angle of the jaw | Pulsatile, moves side to side but not up and down | Wrong position |
Clinical signs related to this case
The signs you should look for in any patient with a thyroid swelling. For each one, know how to elicit it and what a positive result means.
| Sign | How to elicit it, or what you see | What it means |
|---|---|---|
| Is it thyroid | ||
| Moves up on swallowing | Give a sip of water and watch from the front | The swelling is attached to the larynx: thyroid, or a thyroglossal cyst |
| Moves up on protruding the tongue | Hold the lump lightly, mouth open, ask her to put out her tongue | Thyroglossal cyst |
| Signs of size and pressure | ||
| Lower border not felt | Fingers cannot get below the gland when she swallows | The goitre extends behind the sternum |
| Dull percussion over the upper sternum | Percuss the manubrium | Retrosternal goitre |
| Pemberton's sign | Both arms raised beside the head for one minute: the face flushes and neck veins fill | The thoracic inlet is blocked by a retrosternal goitre |
| Displaced trachea | Finger in the notch above the sternum | Large or one-sided goitre pushing the airway |
| Noisy breathing in | Harsh sound on breathing in | The airway is narrowed: urgent |
| Signs of malignancy | ||
| Hard, fixed gland | Does not move well on swallowing | Cancer invading surrounding tissue |
| Hoarse voice | Listen while taking the history | The nerve to the vocal cord is involved |
| Enlarged neck nodes | Feel along the neck on the same side | Spread, typical of papillary cancer |
| Absent carotid pulse (Berry's sign) | Carotid pulse not felt on the side of a large goitre | Cancer surrounding the artery |
| Signs of an overactive thyroid | ||
| Fast or irregular pulse | Count for a full minute | Overactivity; irregular means atrial fibrillation |
| Fine tremor | Paper laid on the outstretched fingers | Overactivity |
| Lid retraction and lid lag | White of the eye visible above the iris; the lid lags behind the eye on looking down | Overactivity of any cause |
| Protruding eyes, thickened shin skin, bruit over the gland | Look from the side and from above; feel the shins; listen over the gland | Graves' disease specifically |
| Signs of an underactive thyroid | ||
| Slow pulse, dry coarse skin, puffy face | Look and feel | Underactivity |
| Slow-relaxing ankle reflex | The foot returns slowly after the tendon is tapped | Underactivity |
Teaching case. The patient is fictional and written to illustrate format and reasoning. Local protocols decide investigation and treatment.